Table 1.

LD25 Monotherapeutic Doses of GLV-1h68, Gemcitabine, and nab-Paclitaxel in Human Pancreatic Carcinoma Cell Lines: Further Employed for Chemovirotherapy

Tumor Cell Line	Virus Dose of GLV-1h68 (MOI)	Gem Concentration (μM)	nab-PTX Concentration (μM)
MIA PaCa-2	0.5	3 × 10−2	5 × 10−3
AsPc-1	0.1	1 × 10−1	1 × 10−2
Panc-1	0.1	7.5 × 10−2	5 × 10−3
BxPc-3	0.01	2 × 10−2	1 × 10−2

Gem, gemcitabine; LD25, 25% lethal dose (determined as the respective concentration of agents used in monotherapy resulting in a remaining tumor cell mass of ∼75% at 72 hr post-treatment); MOI, multiplicity of infection; nab-PTX, nab-paclitaxel.