Fig. 8.

Deficiencies of Nrf1 and Nrf2 distinctly impact the expression of genes involved in glutathione synthesis and redox signaling. Embryos were injected with Control, nrf1a, nrf1b, nrf2a, or nrf2b morpholinos within 1 hpf and allowed to grow until RNA sampling at 96 hpf. Fold change refers to expression relative to the respective Control-MO control in each set of samples. Asterisk (*) indicates a significant difference between respective control and morpholino-injected embryos (p < 0.05). N = 3 samples of 10 embryos for all groups.