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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Nat Chem Biol. 2017 Feb 13;13(4):415–424. doi: 10.1038/nchembio.2297

Figure 1. Design of sugars for controlled metabolic labeling.

Figure 1

(a) Metabolic labeling processes of Ac4ManAz and trigger-activated labeling processes of dormant Ac3ManAz derivatives. P, trigger-removable protecting group. PEP, phosphoenolpyruvic acid. (b) Schematic illustration of ATTACK (active tissue targeting via anchored click chemistry) technology: in vivo selective labeling of cancer cells with azido groups and subsequent cancer targeting via efficient click chemistry.