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Disruption of PGS1 results in loss of mtDNA. (A) Isogenic wild-type (FGY3), ρ0, and pgs1Δ (QZY24B) cells were grown in YPD to early stationary phase. DNA was visualized by staining with DAPI as described in Materials and Methods. (B) Haploid pgs1Δ and ρ- tester strains (100-107) were crossed on a YPD plate. Diploid cells were selected on synthetic minimal medium. Mitochondrial function was determined by assessing growth on nonfermentable medium (YPGE).
