Table 1.
Experimental design and characterization. IBU: Ibuprofen; S244FP: Syloid® 244FP; NS2: Neusilin® US2.
| Carrier | Number | Loading Factors | IBU Crystalline Percentage (%) | Drug Desorption Recovery (%) | Dissolution Efficiency (D.E. %) | |||
|---|---|---|---|---|---|---|---|---|
| IBU Concentration (mg/mL) | Drug to Carrier Ratio | Newly Prepared Samples | Samples after 3-Month Storage | Difference (%) | ||||
| S244FP | SIL_10_1-1 | 10 | 1:1 | 32.7 | 89.8 ± 3.3 | 116.5 | 100.3 | 16.1 |
| SIL_10_1-2 | 10 | 1:2 | 18.9 | 98.2 ± 1.4 | 104.6 | 70.4 | 34.2 | |
| SIL_10_1-3 | 10 | 1:3 | 9.1 | 78.8 ± 2.6 | 128.8 | 76.2 | 52.5 | |
| SIL_25_1-1 | 25 | 1:1 | 33.8 | 109.1 ± 1.1 | 88.9 | 78.1 | 10.7 | |
| SIL_25_1-2 | 25 | 1:2 | 14.1 | 88.2 ± 4.7 | 93.8 | 72.9 | 21.0 | |
| SIL_25_1-3 | 25 | 1:3 | 8.7 | 91.1 ± 1.2 | 134.6 | 84.4 | 50.2 | |
| SIL_40_1-1 | 40 | 1:1 | 30.5 | 107.5 ± 3.6 | 111.6 | 111.6 | 0.0 | |
| SIL_40_1-2 | 40 | 1:2 | 22.3 | 95.6 ± 2.2 | 101.4 | 122.9 | −21.5 | |
| SIL_40_1-3 | 40 | 1:3 | 6.8 | 100.1 ± 4.7 | 122.4 | 88.9 | 33.5 | |
| NS2 | NS2_10_1-1 | 10 | 1:1 | 6.4 | 53.7 ± 2.7 | 114.6 | 69.5 | 45.1 |
| NS2_10_1-2 | 10 | 1:2 | 0 | 46.4 ± 0.3 | 94.4 | 93.1 | 1.3 | |
| NS2_10_1-3 | 10 | 1:3 | 0 | 40.8 ± 1.3 | 128.9 | 109.2 | 19.7 | |
| NS2_25_1-1 | 25 | 1:1 | 4.1 | 52.2 ± 0.7 | 84.8 | 93.3 | −8.5 | |
| NS2_25_1-2 | 25 | 1:2 | 0 | 45.2 ± 0.7 | 85.6 | 97.0 | −11.4 | |
| NS2_25_1-3 | 25 | 1:3 | 0 | 48.4 ± 1.6 | 74.4 | 87.9 | −13.5 | |
| NS2_40_1-1 | 40 | 1:1 | 0 | 54.1 ± 2.2 | 83.3 | 83.3 | 0.0 | |
| NS2_40_1-2 | 40 | 1:2 | 0 | 53.5 ± 0.8 | 97.5 | 57.6 | 39.9 | |
| NS2_40_1-3 | 40 | 1:3 | 0 | 46.9 ± 0.5 | 99.5 | 75.7 | 23.8 | |