Table 3.

Posaconazole trough plasma levels by category

	Number	Median (Range)	Number	Median (Range)	p value
	Female		Male
D2 H0	9	200 (140–660)	9	290 (120–770)	0.86
D4 H0	10	300 (140–1820)	8	580 (260–1090)	0.04
D10 H0	7	770(140–2450)	6	800 (370–1690)	0.84
	BSA<1.9m2		BSA>1.9m2
D2 H0	8	380 (170–660)	10	190 (120–770)	0.27
D4 H0	9	290 (140–1820)	9	420 (250–1090)	0.22
D10 H0	7	810 (380–2450)	6	500 (140– 1690)	0.23
	No IFI		IFI
D2 H0	13	350(140–770)	5	170 (120–270)	0.08
D4 H0	14	410 (200–1820)	4	310 (140–470)	0.19
D10 H0	11	810 (140–2450)	2	640 (510–770)	0.77
	No G3/4 LFT abnormalities		LFT abnormalities
D2 H0	15	200 (140–770)	3	270 (120–490)	0.74
D4 H0	16	410 (140–1820)	2	270 (250–290)	0.21
D10 H0	11	540 (140–2450)	2	980 (770–1180)	0.64

Plasma posaconazole levels presented as ng/ml.

D, day; H, hour; BSA, body surface area; IFI, invasive fungal infection; G, grade; LFT, liver function test