Table 7. Toxicity summary.
| Any Grade | Grade 3 or 4 | |||
|---|---|---|---|---|
| Hematologic Adverse Events | No. | % | No. | % |
| Decreased leukocytes | 11 | 47.83% | 0 | 0.00% |
| Decreased hemoglobin | 10 | 43.48% | 0 | 0.00% |
| Decreased neutrophils | 6 | 26.09% | 2 | 8.70% |
| Decreased platelets | 5 | 21.74% | 0 | 0.00% |
| Lymphopenia | 4 | 17.39% | 0 | 0.00% |
| Non-hematologic Adverse Events | ||||
| Fatigue | 15 | 65.22% | 1 | 4.35% |
| Nausea | 15 | 65.22% | 0 | 0.00% |
| Hyperglycemia | 14 | 60.87% | 1 | 4.35% |
| Vomiting | 13 | 56.52% | 0 | 0.00% |
| Diarrhea | 10 | 43.48% | 0 | 0.00% |
| ALT | 9 | 39.13% | 0 | 0.00% |
| Anorexia | 7 | 30.43% | 0 | 0.00% |
| AST | 6 | 26.09% | 0 | 0.00% |
| Fever | 5 | 21.74% | 1 | 4.35% |
| Hypocalcemia | 5 | 21.74% | 0 | 0.00% |
| Hypokalemia | 5 | 21.74% | 0 | 0.00% |
| Hyponatremia | 5 | 21.74% | 0 | 0.00% |
| Pain—abdomen NOS | 5 | 21.74% | 0 | 0.00% |
| Infection URI | 4 | 17.39% | 0 | 0.00% |
| Constipation | 3 | 13.04% | 0 | 0.00% |
| Flatulence | 3 | 13.04% | 0 | 0.00% |
| Hypomagnesemia | 3 | 13.04% | 0 | 0.00% |
| Hypophosphatemia | 3 | 13.04% | 0 | 0.00% |
| Pain—stomach | 3 | 13.04% | 0 | 0.00% |
| Hyperuricemia | 1 | 4.35% | 1 | 4.35% |
| Infection—catheter related | 1 | 4.35% | 1 | 4.35% |
Notes: Toxicities considered to be at least possibly related. Non-hematological toxicities seen in either > 10% of subjects or ≥ grade 3.