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| Perifosine Dose Level | Patients | Target Perifosine Dose—mg/m2/day | Given Perifosine Dose (standard deviation)—mg/m2/day | Average Plasma Level (standard deviation)—μg/mL; μM |
|---|---|---|---|---|
| 1 | 1,2,3 | 25 | 27 (1.3) | 6.8 (1.6); 18.4 (4.3) |
| 2 | 4,5,6 | 50 | 49 (2.4) | 14.4 (2.5); 39.0 (6.8) |
| 3 | 7,8,9,10,11 | 75 | 74 (5.6) | 11.5 (3.1); 31.1 (8.5) |
| 4 | 12,13,14,15,16,17 | 100 | 110 (9.1) | 12.7 (6.1); 34.4 (16.5) |
| 5 | 18,19,20,21,22 | 125 | 130 (13.1) | 12.1 (3.5); 32.8 (9.5) |
