Table 4. Genetic correlationa between severity of GERD symptoms, inflammation components and metabolic syndrome components.
| WCb | BMIb | SBP | DBP | FPG | DM | TG | HDL-C | Fibrinogen | CRP | |
|---|---|---|---|---|---|---|---|---|---|---|
| General well-being of GERD | 0.26 (0.17) | 0.21 (0.17) | 0.23 (0.19) | 0.30 (0.16) | 0.39 (0.21) | 0.62 (0.27)* | 0.04 (0.22) | 0.03 (0.19) | 0.31 (0.16) | 0.25 (0.19) |
| Acidity complaints | −0.003 (0.17) | −0.09 (0.16) | 0.07 (0.18) | 0.06 (0.16) | 0.40 (0.19)* | 0.49 (0.21)* | 0.27 (0.20) | −0.08 (0.18) | 0.21 (0.16) | 0.13 (0.18) |
| Upper abdominal complaints | −0.18 (0.22) | −0.24 (0.20) | −0.11 (0.22) | 0.02 (0.20) | 0.48 (0.27) | 0.37 (0.33) | 0.12 (0.27) | 0.001 (0.23) | 0.04 (0.21) | 0.13 (0.23) |
| Lower abdominal complaints | 0.04 (0.17) | −0.04 (0.16) | −0.004 (0.18) | 0.13 (0.16) | 0.25 (0.18) | −0.17 (0.22) | −0.13 (0.19) | 0.17 (0.18) | −0.22 (0.17) | −0.07 (0.19) |
| Nausea | −0.13 (0.18) | −0.15 (0.16) | 0.01 (0.18) | 0.02 (0.16) | 0.28 (0.19) | 0.01 (0.23) | 0.27 (0.21) | 0.13 (0.18) | −0.28 (0.18) | −0.04 (0.19) |
| Sleep disturbances | 0.002 (0.16) | 0.06 (0.14) | −0.01 (0.16) | −0.05 (0.14) | 0.36 (0.17)* | 0.23 (0.21) | −0.07 (0.18) | −0.02 (0.16) | −0.12 (0.15) | −0.01 (0.17) |
| Total ReQuest score | 0.02 (0.16) | 0.003 (0.15) | 0.06 (0.16) | 0.09 (0.15) | 0.43 (0.18)* | 0.33 (0.23) | 0.08 (0.19) | −0.04 (0.17) | 0.02 (0.16) | 0.04 (0.18) |
| Fibrinogen | 0.42 (0.11)** | 0.41 (0.11)** | 0.35 (0.14)* | 0.16 (0.14) | −0.20 (0.15) | 0.03 (0.20) | 0.28 (0.16) | −0.05 (0.15) | - | 0.42 (0.11)** |
| CRP | 0.43 (0.12)** | 0.30 (0.11)** | −0.001 (0.13) | −0.15 (0.12) | 0.02 (0.13) | −0.01 (0.16) | 0.15 (0.15) | 0.12 (0.12) | - | - |
Data are presented as ρG(SE).
a All genetic correlations were adjusted for age, sex & BMI except for those that involved WC or BMI.
b The genetic correlation between WC or BMI and another trait was adjusted for age and sex.
* significant genetic correlation at *p < 0.05
** significant genetic correlation **p < 0.01.
GERD, gastroesophageal reflux disease; WC, waist circumference; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; DM, diabetes mellitus; TG, triglycerides; HDL-C, high-density lipoprotein-cholesterol; CRP, C-reactive protein.