TABLE 3.
Severe Transplantation-Related Toxic Effects (From the Start of Conditioning Through Day 180)
| Toxic Effect | No. of Events (%)
|
|||
|---|---|---|---|---|
| HAPLO Arm, n = 60
|
9/10 MUD Arm, n = 46
|
|||
| Grade III | Grade IV | Grade III | Grade IV | |
| Bacterial infection | 37 (62) | 5 (8) | 26 (57) | 5 (11) |
| Viral infection | 18 (30) | 2 (3) | 9 (20) | 1 (2) |
| Fungal infection | 2 (3) | 2 (3) | 3 (7) | 0 (0) |
| Neutropenic fever | 29 (48) | 0 (0) | 13 (28) | 0 (0) |
| Hepatic effecta | 6 (10) | 0 (0) | 3 (7) | 3 (7) |
| Pulmonary effecta | 4 (7) | 0 (0) | 1 (2) | 1 (2) |
| Diffuse alveolar hemorrhage | 1 (2) | 0 (0) | 0 (0) | 0 (0) |
| Renal impairment | 2 (3) | 1 (2) | 5 (11) | 0 (0) |
| Mucositis | 3 (5) | 0 (0) | 2 (4) | 0 (0) |
| Nausea | 2 (3) | 0 (0) | 1 (2) | 0 (0) |
| Diarrhea | 3 (5) | 1 (2) | 9 (20) | 0 (0) |
| Skin rash | 1 (2) | 0 (0) | 1 (2) | 0 (0) |
| Neurologic effecta | 0 (0) | 1 (2) | 0 (0) | 0 (0) |
| Headache | 0 (0) | 0 (0) | 0 (0) | 1 (2) |
| Encephalopathy | 0 (0) | 0 (0) | 0 (0) | 1 (2) |
| Thrombotic microangiopathy | 0 (0) | 0 (0) | 1 (2) | 0 (0) |
| Veno-occlusive disease | 0 (0) | 0 (0) | 1 (2) | 1 (2) |
| Cardiac dysfunction | 0 (0) | 0 (0) | 1 (2) | 1 (2) |
Abbreviations: 9/10 MUD, HLA-mismatched unrelated donor; HAPLO, haploidentical donor.
a
“Hepatic effect” indicates elevation of liver enzymes; “pulmonary effect” indicates hypoxia and/or dyspnea; and “neurologic effect” indicates cerebellar toxicity.