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. Author manuscript; available in PMC: 2017 Jun 5.
Published in final edited form as: Circ J. 2016 Oct 8;80(11):2259–2268. doi: 10.1253/circj.CJ-16-0924

Figure 1.

Figure 1

Role of fatty-acid-binding protein 4 (FABP4) in endoplasmic reticulum (ER) stress-induced apoptosis in atherosclerosis. FABP4, also known as adipocyte protein 2, induces ER stress via LXR-SCD1-mediated de novo lipogenesis. Inhibition of FABP4 and the macrophage lipid chaperone targeting-FABP4 attenuate ER stress-induced apoptosis. Two apoptotic pathways are involved in the action of the ER stress response, including mitochondria-dependent apoptosis and mitochondria-independent apoptosis.