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. 2017 May 19;13(5):e1006786. doi: 10.1371/journal.pgen.1006786

Fig 6. hERG antagonists E-4031 and Dofetilide cause bradycardia.

Fig 6

(A) Histogram of binned diastolic intervals from 12 WtCS hearts before and after exposure to 1μM E-4031 expressed as a percentage of total DIs (totals are show in white for T0 and black for records at 15 min after drug / vehicle exposure). (B) Distribution of DIs in hearts from 14 sei/hERG mutants before and 15 min after exposure to 1μM E-4031. (C) Distribution of DIs in hearts from16 WtCS before and 15 min after exposure to AHL vehicle. (D) Distribution of DIs in hearts from 15 sei/hERG mutants before and 15 min after exposure to AHL vehicle. (E) Average DIs before and after exposure to either 1μM E-4031 or vehicle. (F) Average DIs before and after exposure to either 1μM Dofetilide or DMSO vehicle. Plotted values are mean ± SEM; significance was determined using a two way ANOVA and Sidak’s multiple comparisons test; *** p<0.001; ****p<0.0001.