Fig 12. sei mutations affect wnt gene expression and interact genetically with pygo in the heart.

(A) Schematic diagram of the Wnt signaling pathway highlighting the individual components showing significant down (green) or up (red) regulation in hearts from sei mutants compared to its Wt^CS background control. (B) Diastolic intervals in sei^ts1/ pygo double heterozygotes are significantly longer than for sei^ts1 and pygo single heterozygotes. (C) Systolic intervals in sei^ts1/ pygo double heterozygotes are significantly longer than for sei^ts1 and pygo single heterozygotes. (D) Fractional shortening, a measure of contractility, is significantly reduced in sei^ts1/ pygo double heterozygotes compared to sei^ts1 and pygo single heterozygotes. Significance was determined by one way ANOVA and Tukey’s post-hoc test; **p<0.01, ***p<0.001.