Table 3.
Diagnostic performance of Lp-PLA2 enzyme activity according to different cut-points in the ACS and AIS patients.
| ACS | AIS | |||||
|---|---|---|---|---|---|---|
| AUC SE CI 95% |
0,825 0.053 0,722–0,929 |
0,768 0.059 0,652–0,884 |
||||
| Cut-offa (nmol/ml/min) | 26.1 | 31.4 | 41.1 | 35.5 | 38.1 | 41.9 |
| Sensitivity % CI 95% |
50 34–66 |
71 54–84 |
88 74–96 |
59 42–75 |
75 58–87 |
88 73–96 |
| Specificity % CI 95% |
97 87–100 |
91 79–98 |
49 33–65 |
80 65–91 |
74 55–84 |
46 30–62 |
| PPV % CI 95% |
94 77–99 |
89 73–98 |
63 48–75 |
73 54–87 |
71 54–84 |
60 45–73 |
| NPV % CI 95% |
67 53–78 |
76 62–87 |
81 61–93 |
68 53–81 |
76 59–88 |
80 59–93 |
| (+)LR CI 95% |
17.50 2.89–351.74 |
8.24 2.89–32.17 |
1.72 1.20–2.18 |
2.97 1.41–6.79 |
2.92 1.60–5.32 |
1.61 1.13–2.04 |
| (−)LR CI 95% |
0.52 0.47–0.71 |
0.32 0.24–0.52 |
0.24 0.07–0.66 |
0.51 0.34–0.80 |
0.34 0.17–0.63 |
0.27 0.08–0.75 |
| AR % CI 95% |
74 63–83 |
81 71–89 |
68 57–78 |
70 59–80 |
73 62–83 |
66 54–76 |
ACS: Acute coronary syndrome, AIS: Acute ischemic stroke, AUC: Area under curve, SE: Standard error, CI: Confidence interval, PPV: Positive predictive value, NPV: Negative predictive value, LR: Likelihood ratio, AR: Accuracy rate.
a
The analyzes based on the cut off with high sensitivity appear on the right side of the middle column and those based on cut off with high specificity appear on the left side of the middle column. Middle column represents the optimum cut off values.