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. 2004 Dec 29;5:19. doi: 10.1186/1471-2091-5-19

Table 1.

Ki values and type of inhibition for the interaction of a dead-end inhibitor (FTA) and reaction products (AdoHCy, AFCME) with Icmt. The Km values obtained for the two substrates of the reaction, BFC and AdoMet, are also shown for comparaison.

Substrate\Inhibitor AdoHcy FTA AFCME
BFC Competitive Competitive Noncompetitive
Km = 2.1 ± 0.4 μM 3.59 ± 1.03 μM 1.17 ± 0.16 μM 1.91 ± 0.65 μM
AdoMet Competitive Uncompetitive Mixed-type
Km = 7.8 ± 1.2 μM 3.54 ± 1.12 μM 2.43 ± 0.70 μM