Table 2. Median plasma cytokines in control and HEU groups at different ages, with interquartile values in parenthesis.

	Birth		12 mo		6-12 y		p values
	Control (n=20)	HEU (n=19)	Control (n=19)	HEU (n=19)	Control (n=18)	HEU (n=20)	HEU vs. Control	Control at different ages	HEU at different ages
IL-1β	1.8 (1.0, 6.5)	1.9 (0.9, 6.3)	1.0 (0.8, 1.4)	1.2 (0.7, 1.1)	0.8 (0.5, 1.1)	0.9 (0.7, 1.2)	p>0.05	0.014(birth-12mo) 0.001(birth-6-12y)	0.001(birth-6-12y)
IL-2	2.0 (1.7, 2.1)	2.0 (1.5, 2.0)	2.4 (2.0, 4.5)	2.9 (2.0, 6.4)	2.0 (1.5, 3.0)	2.0 (2.0, 3.0)	p>0.05	0.038(birth-12mo)	0.006(birth-12mo)
IL-4	0.9 (0.6, 1.3)	0.7 (0.6, 1.1)	1.0 (0.7, 1.2)	1.1 (0.8, 1.6)	0.6 (0.5, 0.9)	1.0 (0.7, 1.1)	0.043 (6-12y)	0.024(birth-6-12y) 0.004(12mo-6-12y)	0.017(birth-12mo)
IL-5	4.3 (2.2, 4.4)	2.7 (1.7, 4.4)	4.4 (3.0, 4.4)	4.3 (2.9, 4.4)	4.2 (1.8, 4.4)	4.4 (2.3, 4.4)	p>0.05	p>0.05	p>0.05
IL-6	2.4 (2.4, 2.7)	2.4 (2.5, 3.2)	5.3 (2.5, 9.8)	4.6 (2.7, 8.6)	3.7 (2.5, 7.0)	2.9 (2.5, 5.9)	p>0.05	0.012(birth-12mo) 0.009(birth-6-12y)	0.008(birth-12mo)
IL-7	2.4 (1.9, 3.1)	2.4 (1.8, 2.9)	3.1 (2.6, 3.6)	3.2 (2.1, 3.7)	2.0 (1.7, 3.2)	2.1 (1.6, 2.9)	p>0.05	0.031(birth-12mo)	0.023(12mo-6-12y)
IL-8	3.8 (3.8, 20.2)	5.5 (3.8, 7.4)	3.8 (3.6, 5.7)	3.8 (3.4, 3.8)	3.8 (3.8, 3.8)	3.8 (3.0, 3.8)	p>0.05	0.029(birth-6-12y)	0.007(birth-12mo) 0.004(birth-6-12y)
IL-10	1.4 (1.0, 1.9)	1.4 (0.9, 2.0)	4.7 (2.7, 10.6)	4.1 (1.5, 7.4)	3.8 (1.4, 6.6)	2.6 (1.4, 14.1)	p>0.05	0.001(birth-12mo) 0.007(birth-6-12y)	0.001(birth-12mo) 0.002(birth-6-12y)
IL-12 (p70)	1.1 (0.9, 2.1)	1.1 (0.8, 1.4)	3.0 (2.1, 5.0)	1.9 (1.3, 3.7)	2.2 (1.3, 3.3)	1.8 (1.3, 3.7)	p>0.05	0.001(birth-12mo) 0.028(birth-6-12y)	0.001(birth-12mo) 0.003(birth-6-12y)
IL-13	2.6 (2.2, 2.8)	2.4 (2.0, 2.6)	4.0 (2.9, 6.1)	4.0 (2.7, 5.0)	3.7 (2.5, 5.5)	4.8 (3.1, 6.6)	p>0.05	0.001(birth-12mo) 0.019(birth-6-12y)	0.001(birth-12mo) 0.001(birth-6-12y)
IL-17	3.3 (3.0, 5.2)	3.0 (2.4, 4.2)	4.1 (3.1, 6.0)	4.5 (2.9, 6.9)	3.0 (1.6, 4.0)	3.0 (2.2, 3.2)	p>0.05	0.018(birth-12mo)	0.006(12mo-6-12y)
IFN-γ	35.5 (25.5, 59.7)	36.2 (18.7, 57.7)	43.7 (37.1, 62.0)	53.2 (30.3, 74.0)	31.6 (19.4, 44.7)	31.7 (24.3, 42.7)	p>0.05	0.029 (12mo-6-12y)	0.029(birth-12mo) 0.019 (12mo-6-12y)
TNF-α	12.0 (7.2, 15.0)	8.5 (4.8, 11.1)	12.8 (10.9, 20.7)	22.4 (8.7, 25.1)	7.7 (5.8, 13.6)	10.5 (6.6, 13.4)	p>0.05	0.015 (12mo-6-12y)	0.001(birth-12mo) 0.031 (12mo-6-12y)
G-CSF	8.9 (5.6, 11.4)	7.9 (5.4, 13.2)	11.4 (7.9, 16.6)	11.3 (6.6, 14.7)	5.8 (4.2, 8.2)	6.0 (4.4, 8.2)	p>0.05	0.049(birth-6-12y) 0.001 (12mo-6-12y)	0.001 (12mo-6-12y)
GM-CSF	41.3 (25.1, 53.9)	33.1 (27.9, 51.1)	43.6 (32.3, 52.4)	51.3 (25.5, 77.9)	20.6 (16.5, 34.1)	26.6 (19.7, 34.3)	p>0.05	0.004(birth-6-12y) 0.002 (12mo-6-12y)	0.050(birth-6-12y) 0.001 (12mo-6-12y)
MCP-1	13.2 (9.2, 15.5)	14.4 (8.5, 26.1)	24.0 (19.6, 36.0)	22.4 (18.5, 32.7)	17.7 (11.6, 45.3)	20.1 (15.7, 27.6)	p>0.05	0.001(birth-12mo) 0.017(birth-6-12y)	0.006(birth-12mo)
MIP-1β	31.7 (22.5, 81.2)	41.2 (24.6, 93.2)	46.0 (29.1, 71.0)	23.9 (21.5, 35.4)	28.0 (19.8, 61.7)	25.2 (19.6, 38.8)	0.009 (12mo)	p>0.05	0.023(birth-12mo) 0.028(birth-6-12y)