Table 3. Median T lymphocytes subset percentages in -control and HEU groups at different ages, with interquartile values in parenthesis.

Parameters	Birth		12 mo		6-12 y		p values
	Control	HEU	Control	HEU	Control	HEU	HEU vs. Control	Control at different ages	HEU at different ages
CD4+ T cells
%CD38+ HLA-DR+	1.4 (1.2, 2.0)	1.8 (1.7, 2.2)	4.0 (2.8, 5.9)	2.3 (1.5, 4.6)	1.7 (1.6, 2.2)	2.9 (2.0, 4.9)	0.006 (6-12y)	0.005(birth-12mo) 0.005(12mo-6-12y)	0.038(birth-6-12y)
% PD-1+	3.2 (2.2, 4.5)	1.8 (1.3, 3.4)	10.4 (9.2, 14.8)	10.9 (5.5, 23.5)	10.4 (7.4, 13.6)	12.0 (8.3, 18.5)	p>0.05	0.008(birth-12mo) 0.004(birth-6-12y)	0.002(birth-12mo) 0.001(birth-6-12y)
% 2B4+	1.9 (0.2, 2.6)	1.7 (0.7, 3.1)	5.9 (4.2, 7.5)	2.1 (0.7, 5.3)	5.4 (2.3, 10.0)	10.3 (4.4, 16.1)	p>0.05	0.030(birth-12mo) 0.004(birth-6-12y)	0.001(birth-6-12y) 0.002(12mo-6-12y)
CD8+ T cells
%CD38+ HLA-DR+	12.1 (9.3, 15.9)	9.6 (6.8, 15.5)	12.2 (8.2, 15.3)	18.6 (16.0, 25.6)	5.6 (4.4, 6.9)	7.8 (5.9, 14.3)	0.053 (12mo)	0.001(birth-6-12y)	0.011(birth-12mo) 0.001(12mo-6-12y)
% PD-1+	7.8 (6.2, 11.3)	4.9 (4.2, 8.0)	18.6 (11.5, 26.2)	15.3 (10.8, 24.3)	11.6 (7.4, 15.1)	6.3 (3.7, 22.5)	p>0.05	0.026(birth-12mo)	0.009(birth-12mo)
% 2B4+	14.7 (11.9, 23.1)	14.7 (12.4, 20.1)	57.4 (41.3, 60.4)	40.5 (30.9, 53.2)	44.8 (38.3, 56.1)	48.9 (44.0, 66.0)	p>0.05	0.001(birth-12mo) 0.001(birth-6-12y)	0.008(birth-12mo) 0.001(birth-6-12y)