Figure 2.
ATLa treatment ameliorates markers of tissue repair. Lungs were removed from animals on Days 14 and 21 after treatment with saline, BLM (0.06 U/mouse), BLM plus ATLa late treatment (1 μg/mouse and boosted 0.1 μg/mouse on Days 7 and 10, respectively), or BLM plus BOC-2 with ATLa (100 μg/mouse and 10 μg/mouse of BOC-2 on Days 7 and 10). Immunolabeling for collagen 1 (A–C), TGF-β (D–G), SP-C (H–L, Day 14), and SP-C on Day 21 (K–O) and vascular endothelial growth factor (P–R) as described in Materials and Methods (n = 6 for each experimental group). Pictures are representative of each group. *P < 0.05 compared with saline group; #P < 0.05 compared with BLM group.