Table 4.

Antitumor effects of bisdioxopiperazines of different schedules on Lewis lung carcinoma: *Administration every 3 hours, 16 mice were included in each testing group. **p < 0.05 (treatment vs control), Experimental term was 11 days

Compounds	Dosage	Schedule	Tumor weight	Tumor inhibition
	mg/kg	1, 5, 9 administrations	(g)	%
Control	--	--	2.36 ± 0.05
Razoxane	80	1 time a day	2.49 ± 0.05	-5.5
Razoxane	40	1 time a day	2.32 ± 0.07	1.7
Razoxane	20	1 time a day	2.80 ± 0.06	-18.6
Razoxane	10	3 times a day*	1.51 ± 0.04**	36.0
Probimane	20	3 time a day*	1.19 ± 0.05**	49.6