Table 1. Overview of miRNA profiling studies in CAVD.
This table provides an overview of the differentially expressed miRNAs in diseased AV tissues. AI, aortic insufficiency; TAV, tricuspid aortic valve.
| miRNA | Tissue | Finding | Method | Patients | Reference |
|---|---|---|---|---|---|
| 26a, 30b, 195 | Whole bicuspid AVs | Down-regulated | Microarray + RT-qPCR | 9 BAV patients with AS/AI | [69] |
| 30e, 32, 145, 151-3p, 152, 190, 373, 768-5p 22, 27a, 124-3-pre, 125b-1-pre, 141, 185-pre, 187, 194, 330-5p, 377, 449b, 486-3p, 551a-pre, 564, 566-pre, 575, 622, 637, 648-pre, 1202, 1282, 1469, 1908, 1972 | Bicuspid and tricuspid AVs | Up-regulated Down-regulated | Microarray + RT-qPCR | 19 BAVs 17 TAVs patients with AS | [66] |
| 30b | Calcific AV and adjacent tissue | Down-regulated | RT-qPCR | 10 patients with AS | [67] |
| 148-3p | Excised AV tissue | Down-regulated | RT-qPCR | 4 BAVs compared with healthy AV | [64] |
| 125b 374b, 602, 939 | Calcific AV and healthy AV | Up-regulated Down-regulated | Microarray + RT-qPCR | 20 patients with AS | [63] |
| 214 | Porcine AV | Up-regulated | Microarray + RT-qPCR | Ex vivo shear stress calcification model | [20] |