. 2017 Jun 5;12(6):e0178839. doi: 10.1371/journal.pone.0178839

Table 3. Associations between local European ancestry and POP in top regions.

Region	Nearby Genes	Classification	Ancestry OR (95% CI)	P_case-control	P_case-only^c
15q26.2	RGMA, CHD2	Grade 0 vs. 2/3	0.35 (0.22, 0.57) ^a	1.48x10^-5	7.95x10^-5
15q26.2	RGMA, CHD2	Grade 0 vs. 1–3	0.77 (0.59, 0.99) ^b	0.049	-
1q42.1–42.3	ARID4B, TBCE, ACTN2, PGBD5, ACTA1	Grade 0 vs. 1–3	1.69 (1.28, 2.22) ^b	1.93x10^-4	6.7x10-4
1q42.1–42.3	ARID4B, TBCE, ACTN2, PGBD5, ACTA1	Grade 0 vs. 2/3	1.86 (1.26, 2.76) ^a	2.00x10^-3	-

OR: Odds Ratio; CI: Confidence Interval.

a Modeled against local European ancestry adjusted for covariates (age at ascertainment, BMI, parity and continuous axes of MDS components)

b Modeled against local European ancestry adjusted for covariates (age at ascertainment, BMI, parity and continuous axes of MDS components)

c Case-only p-values were used along with case-control p-values to find overlapping regions.