Table 5. Associations between local ancestry and POP with and without adjustment for genetic markers in top regions.
| Classification | Region | Adjusted for SNP | Ancestry OR (95% CI) a | P |
|---|---|---|---|---|
| Grade 0 vs. 2/3 | 15q26.2 | No | 0.35 (0.22, 0.57) | 1.48x10-5 |
| rs4777810 | 0.50 (0.30, 0.85) | 0.01 | ||
| Grade 0 vs. 2/3 | 1q42.1–42.3 | No | 1.69 (1.28, 2.22) | 1.93x10-4 |
| rs78992478 | 1.56 (1.18, 2.06) | 1.75x10-3 | ||
| rs2501094 | 1.48 (1.11, 1.97) | 6.80x10-3 | ||
| rs78992478 + rs2501094 | 1.37 (1.03, 1.32) | 0.03 |
SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; CI: Confidence Interval; P: P-value
a Modeled against local European ancestry adjusted for covariates (age at ascertainment, BMI, parity and continuous axes of MDS components), with and with and without adjustment for top imputed/genotyped marker(s) at region of interest.