Table 1.
Fragile X checklist data from 188 males with and without fragile X syndrome
| Parameters | Fragile X males % (no. observed/total) | Non fragile X males % (no. observed/total) | Chi square value |
|---|---|---|---|
| Mental retardation | 100.0% (19/19) | 99.4% (168/169) | 1.761 |
| Large ears | 94.7% (18/19) | 49.9% (75/167) | 15.007d |
| Large testes | 84.2% (16/19) | 23.7% (37/156) | 26.559d |
| Plantar crease* | 83.3% (15/19) | 12.2% (20/164) | 48.365d |
| Hyperactivity | 73.7% (14/19) | 26.9% (45/167) | 15.115d |
| Family history of mental retardation or autism | 73.7% (14/19) | 41.6% (64/154) | 5.812a |
| Short attention span | 63.2% (12/19) | 19.3% (32/166) | 15.769d |
| Tactilely defensive | 63.2% (12/19) | 18.7% (31/166) | 16.498d |
| Hyperextensible finger joints | 57.9% (11/19) | 17.6% (29/165) | 13.996c |
| Perseverative speech | 52.6% (10/19) | 11.0% (10/91) | 15.630d |
| Hand-flapping | 47.4% (9/19) | 15.8% (26/165) | 9.096b |
| Pale blue eyes* | 42.1% (8/19) | 13.5% (21/155) | 7.988b |
| Hand-biting | 36.8% (7/19) | 26.7% (44/165) | 0.446 |
| Poor eye contact | 36.8% (7/19) | 25.6% (40/156) | 0.587 |
| Simian crease or Sydney line | 36.8% (7/19) | 4.2% (7/165) | 21.329d |
a
p < 0.05;
b
p < 0.01;
c
p < 0.001;
d
p < 0.0001;
*
Parameter in addition to Hagerman’s Checklist (Hagerman 1987).