Table 2.
Weight change from baseline at 3, 12, and 24 months
|
Weight change from baseline, kg (SE) |
Behavioural programme vs brief intervention (one-sided) |
52-week programme vs 12-week programme (two-sided) |
|||||
|---|---|---|---|---|---|---|---|
| Brief intervention | 12-week programme | 52-week programme | Adjusted difference (95% CI) | p value | Adjusted difference (95% CI) | p value | |
| 3 months | −2·04 (0·30) | −4·84 (0·19) | −4·62 (0·17) | −2·67 (−3·28 to −2·07) | <0·0001 | 0·22 (−0·26 to 0·69) | 0·371 |
| 12 months | −3·26 (0·68) | −4·75 (0·35) | −6·76 (0·42) | −2·71 (−3·86 to −1·55) | <0·0001 | −2·14 (−3·05 to −1·22) | <0·0001 |
| 24 months | −2·30 (0·73) | −3·00 (0·37) | −4·29 (0·44) | −1·44 (−2·87 to 0·00*) | 0·0247 | −1·32 (−2·46 to −0·18) | 0·0231 |
Missing at random analysis with 20 imputed datasets (N=1267 at each timepoint). Treatment effects obtained from mixed-effects models with residuals structured as a first-order auto-regressive process stratified by treatment group. Adjusted differences are shown between combined treatment groups (12-week programme and 52-week programme) versus brief intervention (test 1) and 52-week programme versus 12-week commercial programme (test 2). Analyses are adjusted for baseline observation and centre.
*
Rounded from <0·00.