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. 2017 Jun 5;7:2762. doi: 10.1038/s41598-017-02884-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of antipsychotic drugs on the SREBP and ChREBP pathway. Western blot analysis of the protein expression of hepatic (A) nuclear SREBP-1c, (B) nuclear SREBP-2, and (C) nuclear ChREBP protein after 9-week treatment of OLZ and CLZ. A representative blot is shown (D and E). The mRNA expression of their target genes was quantified and normalized to β-actin and gapdh by qPCR: Fasn (F), Acc1 (G), Scd1 (H), Hmgcr (I), and Ldlr (J). Data represent mean ± SEM of 2 independent experiments done in duplicate (n = 6 per group). *p < 0.05, **p < 0.01, and ***p < 0.001: OLZ treatment vs. control, ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001: CLZ treatment vs. control. C: control; OLZ: olanzapine; CLZ: clozapine.