Table 1.
Plasma glucose, insulin, and NEFA levels in response to one dose and 8-week drug treatment.
| Characteristic | Control n = 12 | OLZ n = 12 | CLZ n = 12 | |
|---|---|---|---|---|
| Glucose | ||||
| Day 1 after one dosetreatment | Fasting levels, mmol/L | 6.51 ± 1.26 | 6.15 ± 0.73 | 6.45 ± 0.84 |
| 0 min postglucose-challenge, mmol/L (2 h after drug administration) | 6.75 ± 1.28 | 6.92 ± 1.29 | 7.27 ± 0.79 | |
| 30 min postglucose-challenge, mmol/L | 14.51 ± 5.45 | 14.11 ± 5.27 | 18.58 ± 7.20 # | |
| 120 min postglucose-challenge, mmol/L | 4.91 ± 1.02 | 5.82 ± 1.91 | 10.87 ± 8.07 ## | |
| AUC | 1241 | 1339 | 2200 # | |
| After 8-week treatment | Fasting levels, mmol/L | 6.32 ± 0.86 | 6.37 ± 0.81 | 5.86 ± 0.56 |
| 0 min postglucose-challenge, mmol/L (2 h after drug administration) | 6.34 ± 0.50 | 6.64 ± 0.89 | 6.40 ± 0.98 | |
| 30 min postglucose-challenge, mmol/L | 16.34 ± 4.49 | 18.76 ± 5.53 | 23.91 ± 5.18 ## | |
| 120 min postglucose-challenge, mmol/L | 6.03 ± 1.81 | 8.43 ± 6.76 | 11.48 ± 6.81 # | |
| AUC | 1493 | 1872** | 2496 ## | |
| Insulin | ||||
| Day 1 after one dose treatment | Fasting levels, uU/mL | 10.78 ± 1.15 | 10.30 ± 1.70 | 10.79 ± 1.94 |
| 0 min postglucose-challenge, uU/mL (2 h after drug administration) | 11.39 ± 2.97 | 14.13 ± 4.99 | 13.29 ± 3.13 | |
| 30 min postglucose-challenge, uU/m | 68.88 ± 23.20 | 66.03 ± 28.30 | 71.73 ± 27.44 | |
| Insulin: Glucose Ratio (30 min) | 4.74 | 4.68 | 3.86 | |
| Fasting levels, uU/mL | 11.01 ± 0.90 | 14.79 ± 0.90* | 8.93 ± 0.92 | |
| After 8-week treatment | 0 min postglucose-challenge, uU/mL (2 h after drug administration) | 13.10 ± 1.95 | 19.29 ± 698** | 10.63 ± 5.96 |
| 30 min postglucose-challenge, uU/mL | 72.25 ± 18.00 | 103.34 ± 30.26* | 49.92 ± 25.37 # | |
| Insulin: Glucose Ratio (30 min) | 4.42 | 5.51* | 2.09 ## | |
| NEFA | ||||
| Day 1 after one dose treatment | Fasting levels, mmol/L | 0.40 ± 0.18 | 0.39 ± 0.21 | 0.38 ± 0.15 |
| 0 min postglucose-challenge, mmol/L (2 h after drug administration) | 0.38 ± 0.10 | 0.51 ± 0.17* | 0.46 ± 0.14 | |
| After 8-week treatment | Fasting levels, mmol/L | 0.37 ± 0.15 | 0.37 ± 0.12 | 0.41 ± 0.09 |
| 0 min postglucose-challenge, mmol/L (2 h after drug administration) | 0.37 ± 0.06 | 0.46 ± 0.10** | 0.39 ± 0.06 | |
Data were obtained from 12 rats per group and represent mean ± SD. Biochemical determinations were made in duplicate (*p < 0.05 and **p < 0.01: OLZ treatment vs. control, # p < 0.05 and ## p < 0.01: CLZ treatment vs. control).