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. 2017 Jun 5;7:2807. doi: 10.1038/s41598-017-02901-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knock-down of Hace1 induces NF-kB expression and activity. (A–C) Knock-down of Hace1 in NKX6.3 stable cells induced expression of NF-kB p65 (A), p50 (B) and DNMT1 (C) mRNA transcript in real-time PCR analysis. Results are represented as mean ± SEM from three independent experiments. (D) In NKX6.3 stable cells, silencing of Hace1 with siHace1 increased NF-kB p65, p50 and DNMT1 protein expression. (E) Knock-down of Hace1 induced DNMT1 activity in NKX6.3 stable cells. Results are represented as mean ± SEM from three independent experiments. Each dot plot represents the result from the individual experiment. *P < 0.05, based on the student’s t-test.