Table 4.

Unconditional logistic analysis of possible risk factors associated with the development of RP.

Risk factors	NSCLC patients with RP ≥G2		NSCLC patients with RP ≥G3		SCC patients with RP ≥G2		SCC patients with RP ≥G3
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Age	1.028 (0.980–1.079)	0.259	1.078 (1.004–1.157)	0.037	1.043 (0.972–1.120)	0.240	1.058 (0.966–1.159)	0.221
PE Grade	1.985 (1.174–3.354)	0.010 a	2.275 (1.141–4.533)	0.020 a	3.304 (1.555–7.023)	0.002 a	2.718 (1.096–6.740)	0.031 a
FVC	2.403 (0.960–6.017)	0.061	1.131 (0.321–3.980)	0.848	3.681 (0.974–13.914)	0.055	2.049 (0.381–11.020)	0.403
PO2	1.002 (0.964–1.041)	0.928	0.986 (0.936–1.039)	0.597	0.951 (0.892–1.013)	0.119	0.958 (0.884–1.038)	0.292
MLD	1.129 (0.962–1.326)	0.137	1.192 (0.951–1.493)	0.128	1.170 (0.925–1.481)	0.191	1.336 (0.967–1.844)	0.079

^a P for the trend of grade 0, Grade 1 and Grade ≥2; RP, radiation pneumonitis; OR, odds ratio; NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma; G2, Grade 2; G3, Grade 3; PE, pulmonary emphysema; FVC, forced vital capacity; PO₂, arterial partial pressure of oxygen; MLD, mean lung dose. Significant differences are indicated in bold.