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. 2017 Jun 6;8:284. doi: 10.3389/fphar.2017.00284

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Copyright © 2017 Qi, Wang, Duan, Lu and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Leonurine increases VEGF expression in senescent HUVECs via activation of HIF-1α. (A) The effects of aging and leonurine on HIF-1α expression in HUVECs detected by Western-blot. (B) The effects of aging and leonurine on the binding of HIF-1α to VEGF gene promoters detected by chromatin immunoprecipitation (ChIP). (C,D) Leonuine restores the expresssions of HIF and VEGF compromised by myxothiazol, an inhibitor of mitochondrial complex III. ^∗p < 0.05 vs. young group; ^∗∗p < 0.01 vs. young group; ^##p < 0.01 vs. senescent group. Data are mean ± SEM.