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. 2017 Jun 6;8:255. doi: 10.3389/fneur.2017.00255

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Copyright © 2017 Gómez-Pinedo, Sirerol-Piquer, Durán-Moreno, García-Verdugo and Matias-Guiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered cell differentiation. Changes in cell differentiation are apparent at 7 days after transfection. Percentages of cells undergoing differentiation were similar between cultures transfected with the wild-type hGFAP protein and those observed under normal conditions. Cultures containing different transfected glial fibrillary acidic protein (GFAP) mutations exhibited higher percentages of GFAP-expressing cells as well as lower percentages of differentiated oligodendrocytes (Olig2) and neurons (Tuj1). These data are statistically significant (*p < 0.05).