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. 2017 Jun 6;8:255. doi: 10.3389/fneur.2017.00255

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Copyright © 2017 Gómez-Pinedo, Sirerol-Piquer, Durán-Moreno, García-Verdugo and Matias-Guiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphs of caspase-3 expression in the oligodendroglial lineage. Increased cell death was observed in cells transfected with mutant glial fibrillary acidic protein (GFAP) at days 3 and 7. The increase in cell death was more marked on day 3 in cells expressing Olig2, an oligodendrocyte marker (*p < 0.05). On day 7, the percentage of cell death was lower, but the difference was still statistically significant (*p < 0.05). This indicates that cell death occurs more frequently in early stages of cell differentiation.