Table 2:

Tests of rate heterogeneity acting on SET genes in insects.

	Gene	One Ratio Likelihood	One Ratio ω	Free Ratio Likelihood	df	P
	Smyd3	−4833.870633	0.055	−4833.870633	16	<0.001
	Smyd4-1	−17270.854806	0.1627	−17140.293096	58	<0.001
SMYD	Smyd4-2	−13187.367961	0.1125	−13112.105983	44	<0.001
	Smyd4-3	−20488.963155	0.1069	−20364.991393	66	<0.001
	Smyd4-4	−15552.366084	0.1112	−15475.97917	44	<0.001
	Smyd5	−21495.435476	0.0633	−21329.013029	64	<0.001
	upSET(MLL5)	−7286.598116	0.0103	−7247.800191	62	0.087
	Set8	−6450.096636	0.0321	−6386.997507	60	<0.001
	Hmt4-20	−3523.660744	0.0079	−3478.339497	56	<0.001
SETD	SETD	−9030.115692	0.033	−9009.972504	34	0.212
PRDM	Blimp-1	−2679.981724	0.0051	−2664.129882	52	0.988
	Mes-4	−5530.425067	0.0163	−5504.225668	56	0.612
Ash	ash1	−4995.315864	0.0122	−4947.987993	60	<0.001
	Set2	−5636.021533	0.0118	−5570.266003	60	<0.001
	Su(var)3-9	−4351.473377	0.0212	−4308.872564	32	<0.001
Suv	egg	−15308.272711	0.0624	−15214.544773	54	<0.001
	CG4565	−7168.675146	0.056	−7114.254055	46	<0.001
	G9a	−4641.585219	0.0091	−4604.810574	54	0.040
	trx	−3897.22035	0.0031	−3877.624919	58	0.972
Trx	Set1	−3733.003015	0.0026	−3700.07484	60	0.281
	trr	−4549.712	0.0114	−4471.116449	60	<0.001
E(z)	Ez	−3368.302419	0.0007	−3355.922925	61	1.000
	SmydA-1	−10066.858829	0.0904	−9995.276076	34	<0.001
	SmydA-2	−11858.796558	0.0052	−11812.616411	30	<0.001
	SmydA-3	−13902.688419	0.0817	−13842.811542	56	<0.001
SMYDA	SmydA-4	−9602.742487	0.0254	−9583.599425	26	0.057
	SmydA-5	−13748.769161	0.1179	−13656.268493	50	<0.001
	SmydA-6	−12142.197791	0.1623	−12043.993185	42	<0.001
	SmydA-9	−13258.406279	0.1357	−13193.536113	52	<0.001

Accounting for the unequal genome sequencing efforts between different insect families, we selected one species within each genus to be representative of the genus.