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. 2017 Jun 6;8:219. doi: 10.3389/fneur.2017.00219

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Copyright © 2017 Kawoos, McCarron and Chavko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in intracranial pressure (ICP) with various schedules of blast overpressure (BOP) exposure. Comparison between N-acetylcysteine amide (NACA)- and phosphate-buffered saline (PBS)-treated groups when administered after BOP exposure. (A) 1 × 72, (B) 3 × 72, (C) 1 × 110, (D) 3 × 110, (E) 3 × 110-2i, and (F) 3 × 110-3d. X-axis label is not to scale. B, blast; Inj, injection of NACA/PBS. Significant difference in ICP between a given time point and the one preceding it within a group is shown by * in PBS-treated and ^ in NACA-treated groups (one-way ANOVA); and between the two groups is shown by # (two-way RM ANOVA), with p < 0.05.