Table 4.

Pharmacokinetic parameters important for oral bioavailability and protein binding parameters of synthesized compounds

Comp	% ABS	MW	Volume	Donor HB	Acceptor HB	Lipinski’s violation	QPlogPo/w
Rule	<80% is high, >25% is poor	<500	500.0–2,000.0	<5	<10	≤1	−2.0 to 6.5
1A	100	395.316	1,041.638	0	1	1	6.493
2A	100	439.369	1,168.198	0	1.75	1	6.799
3A	100	436.525	1,261.8	0	4	1	6.007
4A	100	392.472	1,138.921	1	3.25	1	5.196
5A	100	425.342	1,105.697	0	1.75	1	6.476
6A	100	436.525	1,261.747	0	4	1	6.006
7A	100	332.419	1,011.802	1	1.75	1	5.108
8A	100	394.92	1,041.638	0	1	1	6.493
9A	100	394.92	1,159.867	0	1.75	1	6.724
10A	100	364.892	1,065.077	0	1	1	6.576
11A	100	380.891	1,097.431	0	1.75	1	6.402
12A	100	350.865	1,033.256	0	1	1	6.419
13A	100	394.918	1,159.867	0	1.75	1	6.724
14A	100	394.918	1,159.815	0	1.75	1	6.724
15A	100	364.892	1,095.69	0	1	1	6.741
1B	100	381.289	972.937	0	1	1	6.036
2B	100	336.838	942.479	0	1	1	5.672
3B	100	395.316	1,037.84	0	1	1	6.374
4B	100	425.342	1,080.745	0	1.75	1	6.247
5B	100	395.316	1,016.635	0	1	1	6.264
6B	100	411.315	1,037.038	0	1.75	1	6.018
7B	100	425.342	1,101.954	0	1.75	1	6.357
8B	100	392.472	1,122.39	0	3.25	1	5.516
9B	100	422.498	1,177.838	0	4	1	5.445
10B	100	350.865	1,008.558	0	1	1	6.191
11B	100	380.891	1,072.663	0	1.75	1	6.174
12B	100	336.838	964.548	0	1	1	5.961
13B	100	366.864	1,028.656	0	1.75	1	5.943
14B	100	350.865	1,029.454	0	1	1	6.3
15B	100	380.891	1,093.555	0	1.75	1	6.282

Abbreviations: ABS, absorbance; QPlogPo/w, octanol/water partition coefficients; MW, molecular weight; HB, H-bonds.