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. 2017 May 30;8:15622. doi: 10.1038/ncomms15622

Figure 6. SNP rs16260 affects binding of Argonaute 1 to sense promoter-associated RNA.

Figure 6

(a) Position of SNP rs16260 (blue circle) and isomiR-4534 binding site (green rectangle) in the CDH1 promoter. (b) Allele-specific binding of HA-AGO1 to the −160A and −160C S-paRNA determined by RIP. CD44 mRNA, positive control. (c) Allele-specific binding of endogenous AGO1 to the 160A and −160C S-paRNA determined by RNA-ChIP. (d) Allele-specific binding of AGO1 to the CDH1 promoter with either the 160A and −160C allele determined by ChIP. Data are mean±s.d. of three independent determinations. Student's t-test was used for P value assessment. *P<0.05.