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. 2017 May 30;8:15575. doi: 10.1038/ncomms15575

Figure 7. Promoter accessibility instructs allelic transcription.

Figure 7

(a) ATAC-seq profiles of chromatin accessibility and allelic RNA transcription of representative genes Gng12 (a pro-inflammatory G protein γ subunit), Htatip2 (a pro-apoptotic protein) and Snx20 (an endosome membrane trafficking protein) in pre-B-cell clones. Location of the gene promoter is marked in grey. Total reads, regardless of allelic origin are marked in green, reads identified as originating from the B6 allele based on SNPs are marked in blue, reads identified as originating from the Cast allele based on SNPs are marked in red. (b) Heatmap for allelic ratio of ATAC-seq peaks at promoters and the allelic ratio of transcription in four different pre-B-cell clones. The values are the averages of biological duplicates. Red to blue heatmap indicates linear Cast to B6 levels. Red to blue heatmap indicates linear Cast to B6 levels on a scale from 0 (100% Cast) to 1 (100% B6).