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. 2017 May 31;8:15432. doi: 10.1038/ncomms15432

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Copyright © 2017, The Author(s)

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(a) Schematic illustration of antibody-functionalized LM nanocapsules for target tumour elimination. (b) A mouse with large tumours on its left and right side back 7 days after tumour cell transplantation (day 7). The tumour on the left side back is being irradiated with 785 nm laser. (c) A mouse after 3 days of treatment (day 10) with Anti-EGFR-Biotin-Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM and laser irradiation of the tumour on its left side back. (d) Relative volumes of tumours on the laser-induced left side back. HEPES dispersions of Anti-EGFR-Biotin-Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM (red bars) or HEPES dispersions of Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM (blue bars), or HEPES (black bars) were intratumourally injected and treated with 785 nm laser. Red, blue, and black arrows represent laser irradiation periods for HEPES dispersions of Anti-EGFR-Biotin-Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM-, HEPES dispersions of Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM-, and HEPES-injected mice, respectively. *N.D.: not determined because tumours were completely disappeared. Error bars represent s.d.'s of measurements from three mice. ^aP<0.005; ^bP<0.05; ^cP<0.5; ^dP<0.0005. (e) Relative volume of tumours on the right side back that were injected HEPES dispersions of Anti-EGFR-Biotin-Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM (red bars) or HEPES dispersions of Avidin-DSPE-PEG₂₀₀₀-Amine-DC(8,9)PC-LM (blue bars), or HEPES (black bars) but not subjected to laser irradiation. Error bars represent s.d.'s of measurements from three mice. ^aP<0.5; ^bP<0.005; ^cP<0.05.