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. 2017 May 31;8:15639. doi: 10.1038/ncomms15639

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) A schematic illustration of the nucleation-growth model for HPS aggregation. At each aggregation time point in this model, new nuclei are being formed at a rate of J determined by the classical nucleation theory, and then are growing in size in a barrier-free and diffusion-controlled manner. (b) The free energy change and cooperativity associated with attaching a HPS monomer to aggregates in various DMSO/water solvent mixtures. (c) The time taken for aggregates to grow by one HPS molecule in various solvent mixtures at initial HPS concentration of 6 mM.