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. 2017 Jun 6;8:334. doi: 10.3389/fphar.2017.00334

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Copyright © 2017 Chen, Mo, Wu, Zou, Shi, Gong, Li, Fang, Wang, Yang, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of PI3K/Akt/mTOR insulin pathway by BBr in the mPFC of DM rats. (A–D) BBr reduced the enhanced expressions of p-PI3K ^Tyr467 (A), p-Akt^Ser473 (B), p-GSK3β^Ser9 (C), and p-4E-BP1^Thr37/46 (D) in the mPFC of DM, n = 3∼5 for western-blot. ^∗P < 0.05 vs. NOR; ^∗∗P < 0.01 vs. NOR; ^#P < 0.05 vs. DM; ^##P < 0.01 vs. DM.