1.

Association of nine GCH1 variants with three physiological traits in Tibetans

Traits	SNP_ID	Male (n=91)		Female (n=135)		All (n=226)
		Beta	EMP'	Beta	EMP'	Beta	EMP''	R2(%)
Hb, hemoglobin concentration; NO, blood nitric oxide concentration; SaO2, blood oxygen saturation level. EMP', P value after multiple test corrections; EMP'', P value after multiple test corrections with sex as the covariant.
Hb	rs7148266	-4.33	0.48	-0.53	0.78	-1.51	0.78	0.05
	rs17128004	-3.02	0.65	-0.49	0.86	-1.10	0.86	0.01
	rs4411417	-4.33	0.48	-1.27	0.86	-1.85	0.69	0.23
	rs2183082	1.17	0.86	-2.10	0.57	-0.65	0.86	0.08
	rs10220344	1.17	0.86	-2.10	0.57	-0.65	0.86	0.08
	rs146540091	-62.95	0.05	-17.31	0.25	-35.15	0.02	1.65
	rs117863726	-62.95	0.05	-17.61	0.47	-36.27	0.02	2.39
	rs10136972	12.97	0.03	0.21	1.00	4.28	0.28	1.29
	rs112700866	22.04	0.05	-0.78	1.00	10.25	0.16	0.67
NO	rs7148266	-15.97	0.04	-10.82	0.04	-12.96	2.32E-03	3.05
	rs17128004	-17.23	0.03	-10.77	0.04	-13.42	2.32E-03	3.08
	rs4411417	-15.97	0.04	-11.67	0.04	-13.63	2.75E-03	3.76
	rs2183082	-6.35	0.54	-6.05	0.17	-6.32	0.08	1.28
	rs10220344	-6.35	0.54	-6.05	0.17	-6.32	0.08	1.28
	rs146540091	-162.70	3.53E-03	13.14	0.78	-41.65	0.07	3.36
	rs117863726	-162.70	3.53E-03	13.07	0.65	-41.05	0.07	1.40
	rs10136972	-5.71	0.65	-14.60	0.01	-11.35	0.02	1.88
	rs112700866	-10.98	0.35	4.97	0.73	-2.78	0.86	0.03
SaO2	rs7148266	-0.84	0.38	0.55	0.78	0.05	0.86	0.01
	rs17128004	-1.08	0.33	-0.05	1.00	-0.44	0.48	0.07
	rs4411417	-0.84	0.38	0.57	0.65	0.03	1.00	2.50E-03
	rs2183082	-0.50	0.57	-0.38	0.78	-0.44	0.52	0.03
	rs10220344	-0.50	0.57	-0.38	0.78	-0.44	0.52	0.03
	rs146540091	12.53	0.05	-1.61	0.78	3.07	0.54	3.22
	rs117863726	12.53	0.05	6.66	0.14	8.53	0.02	2.47
	rs10136972	-1.86	0.27	-1.84	0.11	-1.84	0.05	0.75
	rs112700866	-1.68	0.67	-3.46	0.17	-2.76	0.16	0.75