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. 2017 Jun 6;8:233. doi: 10.3389/fneur.2017.00233

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Copyright © 2017 Siracusa, Impellizzeri, Cordaro, Crupi, Esposito, Petrosino and Cuzzocrea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of co-ultraPEALut on histological parameters in hippocampal area after carotid arteries occlusion. Control mice showed large numbers of nerve cells with closely arranged, neat and rounded nuclei in hippocampal (A), in particular in CA1 and CA3 regions (A1,A2), whereas vascular dementia (VaD) mice showed low number of nerve cells and hippocampal disorganized structure (B,B1,B2). Co-ultraPEALut treatment restored the number of neurons to a level comparable to control mice (C) and mice showed a reorganization of hippocampal CA1 and CA3 regions (C1,C2). These data are also visible in the histological score (D). ***p < 0.001 vs. Sham; ^###p < 0.001 vs. VaD, as determined by one-way ANOVA followed by Bonferroni post hoc test.