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. 2017 Jun 6;8:233. doi: 10.3389/fneur.2017.00233

Figure 5.

Figure 5

Effects of co-ultraPEALut on proapoptotic protein in VaD mice. Immunohistochemical analysis showed that Bax was significantly increased after carotid arteries ligation in hippocampal CA1 and CA3 regions [(A,A1,B,B1) vs. (C,C1,D,D1,G)]; instead, treatment with co-ultraPEALut restored Bax expression [(C,C1,D,D1) vs. (E,E1,F,F1,G)]. In addition, Western blot analysis demonstrated Bax expression to be significantly increased in VaD group, whereas treatment with co-ultraPEALut significantly reduced levels of Bad (H,H1). The data are representative of at least three independent experiments. (G) ***p < 0.001 vs. Sham; ###p < 0.001 vs. VaD; (H) **p < 0.01 vs. Sham; ###p < 0.001 vs. VaD, as determined by One way ANOVA followed by Bonferroni post hoc test.