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. 2017 Jun 6;8:233. doi: 10.3389/fneur.2017.00233

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Copyright © 2017 Siracusa, Impellizzeri, Cordaro, Crupi, Esposito, Petrosino and Cuzzocrea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of co-ultraPEALut on antiapoptotic protein in VaD mice. A significantly positive immunostaining for Bcl-2 was found in Sham group and in mice after co-ultraPEALut administration (A,A1,B,B1,E,E1,F,F1,G), while VaD mice showed a decreased expression of Bcl-2 in hippocampal CA1 and CA3 regions (C,C1,D,D1,G). Moreover, Western blot analysis demonstrated that Bcl-2 expression was reduced after carotid arteries occlusion; however, treatment with co-ultraPEALut restored basal levels (H,H1). The data are illustrative of at least three independent experiments. (G) ***p < 0.001 vs. Sham; ^###p < 0.001 vs. VaD; (H) ***p < 0.001 vs. Sham; ^###p < 0.001 vs. VaD, as determined by one-way ANOVA followed by Bonferroni post hoc test.