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In vitro tumor-cell-killing activity of cells expressing an inatinib-resistant mutant of BCR-ABL by ON012380. The four representative imatinib-resistant cell lines T315I (A), E255K (B), Y253H (C), and G250E (D) were incubated with increasing concentrations of the indicated compounds, and the total number of viable cells was determined 72 h after treatment by trypan blue exclusion.
