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. 2017 Jun 6;7:2818. doi: 10.1038/s41598-017-02923-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of A/B compartments. (a) Pearson correlation matrix. The plaid pattern suggests chromatin spatially segregates into two compartments. The assignment of each genomic region into chromatin compartments A/B is shown below. The associated degree of compartmentalization is shown in the left bar. (b) Spatial segregation between chromatin compartments A/B. On the representative modeled conformation, chromatin compartments A and B are shown in red and blue, respectively. (c) Projection of degree of compartmentalization onto representative conformation.