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. 2017 Jun 6;7:2818. doi: 10.1038/s41598-017-02923-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spatial segregation of genome features. (a) Mapping of genome features onto the 3D chromatin structure. The degree of compartmentalization is shown in the center for comparison. Genomic features are presented as smoothed experimental data over different window sizes: 50-kb for LAD and H3K4me3, 200-kb for replication timing, 400-kb for DNase I, 2-Mb for RNA-seq and RNAP II. The maximum/minimum of color bar stands for the value of average +/−standard deviation. The red color represents deficiency of lamina-associated domain (LAD), enrichment of DNase I hypersensitive sites (DNase I), enrichment of RNA polymerase II (RNAP II), active gene expression (RNA-seq), enrichment of active histone modifications (H3K4me3) and early replication timing (Replication Timing). (b) Comparison between replication timing and degree of compartmentalization along the chromosome. (c) Spatial segregation between PMD (blue color) and non-PMD (red color). Domains with size smaller than 300 kb are not grouped into type A or B (cyan color).