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. 2017 Jun 6;7:2818. doi: 10.1038/s41598-017-02923-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of type A and B chromatin. The Hi-C pattern of type A chromatin is different from type B chromatin: (a) Typical Hi-C of type A chromatin (chr1: 15.46–16.54 Mb). (b) Typical Hi-C of type B chromatin (chr1: 233.47–234.50 Mb). The structural modeling illustrates the different structure of type A/B chromatin: (c) Modeled structure of type A chromatin, corresponding to Hi-C data in (a). (d) Modeled structure of type B chromatin, corresponding to Hi-C data in (b). TADs are annotated in Hi-C data (a,b) and correspondingly colored in blocks in (c,d). (e) Composition of type A/B chromatin in PMD/non-PMD. (f) Composition of compartments A/B in type A/B chromatins.