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. 2017 Jun 6;7:2818. doi: 10.1038/s41598-017-02923-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mapping sequence properties and TAD size onto the 3D chromatin structure. (a) CpG density (Colored as the count of CpG in a 50-kb chromosome region). (b) Density of CTCF binding site (Colored as the count of CTCF binding site in a 400-kb chromosome region). (c) TAD size (Colored as the size of TAD in which the genomic region belongs). Compared to chromatin compartment B, compartment A is enriched with CpG dinucleotide, CTCF binding site and has smaller TAD.