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. 2017 Jun 6;7:2818. doi: 10.1038/s41598-017-02923-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of the folding principle of chromosome. Chromatin type A is enriched with CG sequences and CTCF-binding sites. Thus, chromatin type A has relatively smaller chromatin loops compared to chromatin type B. Larger chromatin loops tend to aggregate around nuclear membrane, suggesting an entropy-driven chromatin compartmentalization. Chromosomes with larger median chromatin loops prefer nuclear periphery, also implying an entropy-driven chromosome positioning. The distribution of various genome features are related to chromatin compartmentalization.