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PCSK9-induced degradation of the LDLR depends on exit from the ER. HepG2 cells were infected with empty or PCSK9 adenovirus (Pcsk9). Cells were pulse-labeled with 35S-Met/Cys for 30 min, chased for 4 h in the presence of BFA and BFA plus nocodazole (noc), and immunoprecipitated for the LDLR. M, mature LDLR; P, precursor LDLR.
